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Molecular Microbiology Research (Online) 2012, Vol.2 No.1 1-9
ISSN 1027-5595
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8
Selection of an appropriate drug based on subject
factors, if possible use narrow spectrum antibiotics,
which are more selective and causes less interference
to normal resident bacteria.
Antibiotic activity of particular dose is inversely
proportional to the number of growing bacteria
present. Therefore, in earlier treatment there is more
chance that infectious agents to be caught in their
early logarithmic growth phase. Therapeutic index/
Safety margin consideration.
Effete on infectious agents and host phagocytes
should be in balance (Not deleterious effect on host
phagocytes). If, infection with susceptible bacteria at
usual site then low doses with long interval are
instigated, but less susceptible organisms at remote
site dosage should be elevated (Pappe et al., 1991).
10 Conclusion
Knowledge of types and characteristics of pathogens,
MIC of antimicrobials and drug resistance are having
paramount importance and having aided values in the
treatment of mastitis. Beside the consideration of
pharmacokinetic
alone,
the
relationship
of
pharmacokinetic / pharmacodynamics of antimicrobial
drugs resolve the solution of selection and application
of antimicrobial agents used for rational treatment of
mastitis on basis of pharmacotherapeutic knowledge
.
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