Genomics and Applied Biology 2018, Vol.9, No.1, 1-5
1
Research Report Open Access
Research Progress of Marinobufagenin and Salt-Sensitive Hypertension
Xiaoxiao Fang, Xinghui Jing, Junfeng Wang, Yuan Gao
Zunyi Medical College in Zhuhai campus, Zhuhai, 519000, China
Corresponding author email
Genomics and Applied Biology, 2018, Vol.9, No.1 doi
Received: 15 Nov., 2017
Accepted: 05 Dec., 2017
Published: 12 Jan., 2018
Copyright
© 2018 Fang et al., This is an open access article published under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article
:
Fang X.X., Jing X.H., Wang J.F., and Gao Y., 2018, Research progress of marinobufagenin and salt-sensitive hypertension, Genomics and Applied Biology,
9(1): 1-5 (doi
Abstract
Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it
has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the
unitary ligand of Na
+
/K
+
ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention,
increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na
+
/K
+
ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive
hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.
Keywords
Marinobufagenin; Salt-sensitive hypertension; Na
+
/K
+
-ATPase; Endogenous digitals-like substance
1 Salt-Sensitive Hypertension
Salt is one of the crucial risk factors of essential hypertension. A mass of
, animal
experiments and ecological studies have documented the intimate association between salt and blood pressure.
The different blood pressure response of individuals to salt load showed a discrete distribution, which confirmed
the presence of salt sensitivity. Salt sensitivity is the genetic basis of salt connects hypertension, is an intermediate
genetic phenotype of essential hypertension. The salt sensitivity of blood pressure, defined as an exaggerated
pressor response to dietary salt intake, jointly determined by genetic factors, age, body mass index (BMI),
ethnic factor, increases the risk of hypertension (Carey et al., 2012; Kotchen et al., 2013;
Felder et al., 2013; Frame et al., 2017), and the associated hypertension defined as salt sensitivity hypertension
(salt-sensitive hypertension, SSH). Some people have significant blood pressure increase after high salt intake is
called salt-sensitive subjects, while the other group have no obvious increase in blood pressure is called
non-salt-sensitive subjects. SSH is an important characteristic of hypertension in China, affects approximately
50% of hypertensive patients, 25% of normotensive adults (Kotchen et al., 2013; Felder et al., 2013 ) and about
40% of the teenages have salt sensitivity in positive family history of hypertension (Mou et al, 2012). It is a
complex disease related to regional, ethnic, demographic and social factors, as well as an independent risk factor
for cardiovascular disease.
2 Endogenous Digitals-like Substance and Marinobufagenin
Endogenous digitals-like substance (ELDS)
，
which has similar characters with exogenous digitalis in structure,
physico and chemical properties and biological functionis, is
Endogenous cardenolids
have similar structure with
from plant, including endogenous ouabain (EO) and endogenous digoxin.
Another group is endogenous bufadienolides, including endogenous marinobufagenin (MBG), telocinobufagin
and bufalin
，
which have similar structure wit
that originally discovered in skin of amphibians (Schoner
et al., 2007; Wang et al., 2011). Significantly, MBG has intimate association with salt sensitive hypertension and
involves multiple pathogenesis.
3 Marinobufagenin and Salt Sensitive Hypertension
3.1 Level of marinobufagenin in salt sensitive hypertension
MBG is mainly produced in the hypothalamus and adrenal cortex. Some animal experiments studied ELDS in
