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Computational Molecular Biology 2014, Vol. 4, No. 10, 1-17
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experimental efforts. Serving the guide for genome
and extra-nucleus information flow, histone
modifications can reveal important information for
functional genomic studies. Based on the association
of histone modification co-localization and gene
function, novel measures for gene functional
annotation are promising. Gene similarity measures
can therefore potentially benefit from epigenetic and
expression profiles. Systematic studies of co-localization
will hopefully illuminate the mechanisms of the
distinct underlying genomic characteristics associating
with different co-localizations of H3K4me. Histone
modification co-localization may provide cubic targets
for chromatin regulation, and further efforts should be
paid for functional studies of histone modification
co-localization.
Authors' contributions
JL drafted the manuscript and performed the bioinformatics
analysis. HBL and HL collected data and pre-preprocessing.
QW and YZ conceived of the study, and participated in its
design and coordination. All authors read and approved the
final manuscript.
Acknowledgments
The authors thank National Natural Science Foundation of
China for funding. This work is supported by the National
Natural Science Foundation of China [31171383, 31271558,
31371478, 31371334].
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