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Computational Molecular Biology 2014, Vol. 4, No. 10, 1-17
http://cmb.biopublisher.ca
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2.5 Co-localization of H3K4me with other histone
modification marks
We further correlated all H3K3me co-localization
types to other histone modifications derived from the
HHMD database
to explore
chromatin interactions. From Figure 6, we could
clearly observe that H3K9me1, H3K27me1 and three
H3K79me types were more overlapped with H3K4me
than others. Especially, H3K4me1me2 was a more
prominent mark to co-localize other modifications,
while H3K4me3 was a less likely mark to co-localize
with other modifications. H3K9me1 was most likely
to co-localize with H3K4me, while H3K27me3 was
not found to co-localize with H3K4me. From Figure 6
and Supplementary Figure 1, mono-methylation or
mono-/di-methylation for H3K4 were found to be
associated more with other mono-methylation
modification types.
Figure 6 The boxplot for other histone modification tag number normalized with length for peaks from four types of co-localization
and three types of single-localization