sophisticated line of defense. Dengue viruses have also evolved multiple mechanisms to evade th response. On the one hand, the dengue virus is able to suppress the mosquito's immune system, slowing down the host's resistance to the virus. On the other hand, the host's immune system is also able to recognize and remove infected cells, limiting the spread of the virus in the mosquito. The complexity of this host the efficiency of dengue virus transmission in Figure 4 Host-virus interaction (Image source: Baidu Image Library) The physiological state of the mosquito also has an impact on the spread of the virus. For example, mosquito lifespan, food intake, and the developmental state of the eggs may affect virus spread. The success of the virus in entering the mosquito's salivary glands directly affects 2.3 The replication and spread mechanism of viruses The replication and spread of dengue virus in Once inside the mosquito's gut cells, the virus utilizes host cell mechanisms to begin replication. This involves multiple steps of viral RNA replication, protein synthesis, and other steps that require highly coordinated host-virus interactions. As the virus replicates, a large number of virus particles will accumulate in the infected cells. These viral particles will enter the body fluids of the mosquito through the cellular release mechanism and subsequently spread to other parts of the mosquito. This process of replication and s immune system (Long et al., 2022). The spread of the virus is not limited to the mosquito's body, but also involves how the virus enters the mosquito's salivary glands in preparation for transmis number of factors such as the host's immune response and the rate of viral replication. A virus that successfully enters the salivary glands will greatly increase its chances of transmi Dengue virus transmission in Aedes aegypti and spread mechanisms (Zhang et al., 2019). An in developing effective dengue prevention and control strategies. By revealing the interrelationship between the virus and mosquitoes, it is expected to find ways to intervene in the transmission process and provide new ideas to reduce dengue cases. This study will also provide a useful reference for other mosquito 3 The Impact of Microorganisms on Dengue Fever Virus 3.1 Positive impact: the antiviral effect of microorganisms Aedes aegypti Gut microbes may have a positive effect on dengue virus, with the antiviral effects of microbes being an area of interest. Several studies have suggested that gut microbes may protect against dengue virus by activating the host's immune system or by produ Journal of Mosquito Research 2024, Vol.14, No.1, 1 http://emtoscipublisher.com/index.php/jmr 4 virus in the mosquito. The complexity of this host-virus interaction directly affects Aedes aegypti (Figure 4). virus interaction (Image source: Baidu Image Library) the mosquito also has an impact on the spread of the virus. For example, mosquito entering the mosquito's salivary glands directly affects its ability to be transmitted to a new host through the bite. Aedes aegypti involves the interaction of multiple cells and tissues. gut cells, the virus utilizes host cell mechanisms to begin replication. This involves mber of virus particles will accumulate in the infected cells. These viral particles parts of the mosquito. This process of replication and spread is a dynamic equilibrium that is regulated by the host salivary glands in preparation for transmission to a new host through a bite. This process may be influenced by a enters the salivary glands will greatly increase its chances of transmission, completing the life cycle of the virus. involves a complex life cycle, host-virus interactions, and replication and spread mechanisms (Zhang et al., 2019). An in-depth understanding of these processes is cr This study will also provide a useful reference for other mosquito-borne diseases. activating the host's immune system or by producing antimicrobial substances. 4, Vol.14, No.1, 1-9 sophisticated line of defense. Dengue viruses have also evolved multiple mechanisms to evade the host's immune virus interaction directly affects its ability to be transmitted to a new host through the bite. pread is a dynamic equilibrium that is regulated by the host sion to a new host through a bite. This process may be influenced by a ssion, completing the life cycle of the virus. virus interactions, and replication depth understanding of these processes is crucial for borne diseases.
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