Journal of Mosquito Research 2024, Vol.14, No.1, 49-60 http://emtoscipublisher.com/index.php/jmr 57 Considering the ecological status of non-target insects, using appropriate assessment methods, and implementing effective environmental management recommendations can help mitigate potential ecological risks associated with Rhodococcus erythropolis application. This contributes to mosquito control while protecting ecosystem stability and sustainability, offering dual protection for human health and ecological balance. 6 Policy and Regulatory Framework 6.1 Policies and regulations on the application of biological control technology in different countries and regions Biological control technology, as an effective means of responding to harmful biological invasion, has been widely applied worldwide. Especially in controlling mosquito borne diseases, utilizing technologies such as endophytic bacteria such as Streptococcus has gradually become a part of public health strategies. Different countries and regions have formulated different policies and regulations to regulate the application of biological control technology based on their own legal systems, environmental protection policies, and public health needs. The following is an analysis of policies and regulations in this field in some major countries and regions (Barratt et al., 2018). The Environmental Protection Agency (EPA) of the United States strictly reviews and regulates biological control products. According to the Federal Insecticide, Fungicide, and Rodentide Act (FIFRA), all new biological control products must obtain EPA registration approval before they can be put on the market. In addition, the EPA also evaluates the potential impact of these products on the environment and endangered species under the Endangered Species Act (ESA) and National Environmental Policy Law (NEPA). For example, the EPA conducted extensive environmental impact assessments when approving the use of mosquitoes infected with Streptococcus to control dengue fever transmission, ensuring that irreversible damage to the ecosystem is not caused. The EU has adopted a relatively unified regulatory system for the regulation of biological control products. The European Union has passed the Biological Products Regulations (BPR), which stipulate that all biological control products must obtain approval before being launched in EU member states. This regulation not only covers the safety and effectiveness assessment of products, but also includes a detailed assessment of their environmental impact. The EU regulations emphasize the impact of products on non target organisms, ensuring that biological control measures do not have a negative impact on biodiversity. The Australian government regulates the use of biocontrol products through the Australian Pesticide and Veterinary Products Administration (APVMA). APVMA evaluates the safety, effectiveness, and environmental impact of biological control agents to ensure that all product uses comply with national environmental protection and biosafety standards. Australia is very cautious in the use of biological control technology, especially when introducing non native species for biological control, strict risk assessment and subsequent monitoring must be carried out. The management of biological control products in China involves multiple government departments, including the Ministry of Agriculture and Rural Affairs and the Ministry of Ecology and Environment. The main regulations implemented by China for biological control products include the Pesticide Management Regulations and the Biological Safety Law. These regulations not only regulate the registration, production, sales, and use processes of biological control products, but also emphasize the importance of biosafety and environmental protection. In addition, China is particularly concerned about the potential impact of biological control technologies on local biodiversity, and any biological control project requires environmental impact assessment. The regulations and policies of different countries and regions reflect a common global focus on the regulation of biological control technology, which is to ensure that the application of these technologies is both effective and safe, not only to control pests, but also to protect the environment and biodiversity. With the development of technology and the advancement of globalization, international coordination and cooperation in biological control
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