Journal of Mosquito Research 2024, Vol.14, No.1, 18-25 http://emtoscipublisher.com/index.php/jmr 22 Figure 3 Replication and transmission of sylvatic dengue virus serotype 2 (DENV-2) is similar in native (cynomolgus macaque) and novel (squirrel monkey) hosts Figure 4 reveals the relationship between viral titers in non-human primates and the probability of virus transmission to mosquitoes. For wild-type Dengue virus serotype 2 (DENV-2), transmission to mosquitoes occurred only when the viral titers in serum were below or near the detection limit, while for wild-type Zika virus (ZIKV), the viral titers in serum positively correlated with transmission to mosquitoes. The curve fitted by a generalized additive model shows that the probability of ZIKV transmission to mosquitoes increases with higher viral titers, whereas the transmission probability for DENV-2 peaks at lower viral titers. This finding highlights the differences in replication and transmission capabilities among different viruses within host bodies. Figure 4 Transmission of DENV-2 (in green) from non-human primates to mosquitoes occurred only when serum viremia was below or near the limit of detection, while ZIKV (in blue) transmission was positively associated with serum viremia
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