Journal of Mosquito Research 2024, Vol.14, No.1, 18-25 http://emtoscipublisher.com/index.php/jmr 19 Figure 1 Overview of experimental infections of cynomolgus macaques and squirrel monkeys with dengue virus serotype 2 (DENV-2, in green) and Zika virus (ZIKV, in blue) and subsequent sampling Table 1 shows rhesus monkeys being assigned to low-dose (1 infected mosquito) or high-dose (10 infected mosquitoes) Dengue virus (DENV) experimental groups, or a high-dose (15 infected mosquitoes) Zika virus (ZIKV) experimental group, along with a control group (10 uninfected mosquitoes). The results indicate that the presence days and peak titers of the virus in monkeys varied with different doses of viral infection, with the high-dose ZIKV infection group generally having a higher proportion of virus transmission to mosquitoes than the DENV groups. Moreover, the data in the table reflect the neutralizing efficacy of the neutralizing antibodies produced in monkeys, with some animals not detecting the virus on specific days, suggesting individual differences in the host's immune response to the virus. These data provide experimental evidence for understanding the impact of different viral doses on the host and their transmission capability to mosquitoes.
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