Cotton Genomics and Genetics 2025, Vol.16, No.3, 148-162 http://cropscipublisher.com/index.php/cgg 161 training of interdisciplinary talents, encourage breeding experts to learn data science methods, and cultivate more compound talents who understand both genetic breeding and AI algorithms to open up the "last mile" of technology application. Thirdly, AI breeding should be promoted step by step: starting with easy-to-predict traits such as fiber quality, accumulating experience in practice, and then gradually expanding to complex goals such as yield and stress resistance, step by step, and taking the lead. Fourth, scientific research and production should be closely integrated to strengthen demonstration and application. Select several advantageous cotton-producing areas to establish "intelligent breeding demonstration stations" to actually test the selection effect and economic benefits of AI models, and win the trust of the breeding community with example verification. Finally, formulate relevant standards and specifications to ensure the reliability and repeatability of AI breeding software tools, and avoid waste of resources caused by improper application. In short, we believe that with the joint efforts of all parties in industry, academia and research, the road to AI-enabled cotton breeding will become wider and wider. In the future, the cultivation of new varieties of "super cotton" with high yield, high quality and multi-resistance will no longer rely entirely on the intuition and experience of breeders, but will be accurately obtained through scientific data analysis and prediction with the assistance of artificial intelligence. This will greatly improve breeding efficiency, reduce breeding costs, and promote the quality improvement, efficiency increase and sustainable development of the cotton industry in my country and even the world. The tide of the times is rolling forward, and the integrated development of artificial intelligence and cotton breeding has become a general trend. We have reason to be confident in its bright prospects. Acknowledgments We would like to express my gratitude to the reviewers for their valuable feedback, which helped improve the manuscript. Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. 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