Genomics and Applied Biology 2024, Vol.15, No.1, 8-11 http://bioscipublisher.com/index.php/gab 10 Figure 3Bru1candidate gene locus 3 Evaluation of the Research This research represents a milestone achievement in the field of sugarcane genomics, constructing a complex polyploid reference genome for the sugarcane variety R570 through highly innovative methods. The findings not only deepen the scientific community's understanding of sugarcane's genetic complexity but also significantly advance the application of genomics in sugarcane research, particularly in improving disease resistance and productivity. By thoroughly analyzing key resistance genes like Bru1, this study provides molecular targets for sugarcane disease-resistant breeding and also offers potential resistance mechanisms for other crops. Moreover, the success of this study demonstrates the power of interdisciplinary collaboration, integrating techniques and knowledge from bioinformatics, molecular biology, genetics, and other fields, reflecting the composite and interconnected nature of modern scientific research. The publication of this study not only provides valuable resources for sugarcane breeding and improvement but also offers clues to solving challenges faced by global agricultural production, showcasing the key role of genomic research in modern agricultural science. 4 Conclusions The successful construction of the polyploid reference genome for sugarcane R570 marks a milestone in sugarcane genome research, advancing the study of this important economic crop to a new level. Through the use of the latest sequencing technologies and bioinformatics analysis, this work provides an unprecedented detailed view of sugarcane's genetic diversity and complex genome structure, as well as identifying genes controlling key agronomic traits such as sugar accumulation and disease resistance, providing important molecular markers and candidate genes for future molecular breeding and genetic improvement. Moreover, the outcomes of this research pave the way for advances in sugarcane biotechnology, offering scientific evidence and technical tools for developing new disease-resistant varieties and increasing sugarcane sugar yield. Against the backdrop of global
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