Computational Molecular Biology 2025, Vol.15, No.1, 1-12 http://bioscipublisher.com/index.php/cmb 7 Table 5 Genomic loci encoding major protein families have variable alternatives splicing rates * Pfam Domain Domain Description Total loci AS loci AS (%) pfam07690 MFS_1 Major facilitator superfamily 101 64 63 pfam04082 Fungal_trans Fungal specific transcription factor 75 60 80 pfam00067 p450 Cytochrome P450 58 38 66 pfam00069 Pkinase Protein kinase domain 45 32 71 pfam00083 Sugar_tr Sugar (and other) transporter 44 32 73 pfam00106 adh_short short chain dehydrogenase 41 22 54 pfam12796 Ank_2 Ankyrin repeats (3 copies) 36 24 67 pfam00172 Zn_clus Fungal Zn(2)-Cys(6) binuclear cluster domain 29 25 86 pfam11951 Fungal_trans_2 Fungal specific transcription factor 29 26 90 pfam01494 FAD_binding_3 FAD binding domain 23 16 70 pfam00109 ketoacyl-synt Beta-ketoacyl synthase, N-terminal 22 17 77 pfam00501 AMP-binding AMP-binding enzyme 20 12 60 pfam08240 ADH_N Alcohol dehydrogenase GroES-like domain 20 16 80 pfam00135 COesterase Carboxylesterase family 18 10 56 pfam13561 adh_short_C2 Enoyl-(Acyl carrier protein) reductase 17 11 65 pfam09770 PAT1 Topoisomerase II-associated protein PAT1 16 13 81 pfam00005 ABC_tran ABC transporter 15 12 80 pfam05199 GMC_oxred_C GMC oxidoreductase 15 7 47 pfam05368 NmrA NmrA-like family 15 7 47 pfam00107 ADH_zinc_N Zinc-binding dehydrogenase 14 9 64 pfam00743 FMO-like Flavin-binding monooxygenase-like 14 10 71 pfam01565 FAD_binding_4 FAD binding domain 14 10 71 pfam00076 RRM_1 RNA recognition motif 12 11 92 pfam00153 Mito_carr Mitochondrial carrier protein 12 9 75 pfam00155 Aminotran_1_2 Aminotransferase class I and II 12 6 50 pfam00270 DEAD DEAD/DEAH box helicase 12 6 50 pfam04479 RTA1 RTA1 like protein 12 5 42 pfam06985 HET Heterokaryon incompatibility protein (HET) 12 8 67 pfam07519 Tannase Tannase and feruloyl esterase 12 2 17 pfam13520 AA_permease_2 Amino acid permease 12 10 83 pfam13649 Methyltransf_25 Methyltransferase domain 12 6 50 pfam00171 Aldedh Aldehyde dehydrogenase family 11 6 55 pfam01490 Aa_trans Transmembrane amino acid transporter protein 11 7 64 pfam00400 WD40 WD domain, G-beta repeat 10 8 80 pfam00561 Abhydrolase_1 Alpha/beta hydrolase fold 10 6 60 pfam01425 Amidase Amidase 10 8 80 pfam07992 Pyr_redox_2 Pyridine nucleotide-disulphide 10 5 50 Total - - 2941 2000 68 Note: * Partial list. The full list can be found in supplementary table 4
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