Computational Molecular Biology 2024, Vol.14, No.1, 36-44 http://bioscipublisher.com/index.php/cmb 41 allowed for the identification and quantification of these protein changes (Figure 2), providing a comprehensive view of the host response to bacterial infections. Figure 2 Abundance ratios of new proteins between the mutant and the wt strain and the statistical significance level (Photo credit: Birk et al., 2021) Image caption: Panel (A) presents volcano plots indicating the protein abundance differences between the two strains from 0.5 to 6 hours post-infection, with red dots representing proteins that are significantly different (Padj≤0.05). The numbers in the bottom right corner denote the number of significantly different proteins at each time point. Panel (B) shows a heatmap illustrating the hierarchical clustering based on Euclidean distance of Z-scored abundances of de novo synthesized proteins upon infection. The profile plots on the right display the Z-scored protein levels for the corresponding clusters (Adapted from Birk et al., 2021)
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