Bioscience Methods 2024, Vol.15, No.5, 244-254 http://bioscipublisher.com/index.php/bm 248 serum uric acid levels and improving renal injury and fibrosis in hyperuricemia models (Qian et al., 2022). The plant also shows potential in treating chronic gastritis by influencing inflammatory responses, amino acid synthesis, and energy metabolism (Yang et al., 2020). These diverse pharmacological effects underscore the therapeutic potential of A. macrocephalain various medical conditions (Figure 2). Figure 2 Flowchart of a network pharmacology-based strategy to investigate the pharmacologic mechanisms of Atractylodes macrocephalaKoidz. for treatment of chronic gastritis (Adopted from Yang et al., 2020) Image caption: (A) GO analyses of the 25 gene symbols associated with chronic gastritis. The x-axis represents significant enrichment in the counts of these terms. The y-axis represents the categories of “biological process” in the GO of the target genes (p < 0.01). (B) KEGG pathway enrichment analyses. The x-axis represents the counts of the target symbols in each pathway; the y-axis represents the main pathways (p< 0.01) (Adopted from Yang et al., 2020)
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