Bioscience Evidence 2024, Vol.14, No.6, 250-259 http://bioscipublisher.com/index.php/be 257 Despite the promising health benefits of tea oil, several gaps in knowledge remain that warrant further investigation. Future research should focus on conducting large-scale, high-quality randomized controlled trials to substantiate the therapeutic efficacy of tea oil in various health conditions. Specifically, more studies are needed to explore the molecular mechanisms underlying the anti-inflammatory and antimicrobial actions of tea oil, as well as its potential side effects when used in higher concentrations. Additionally, research should aim to identify the optimal dosages and formulations of tea oil for different therapeutic applications. Investigating the long-term effects of tea oil consumption on metabolic health and its impact on gut microbiota could provide valuable insights into its role in managing chronic diseases such as diabetes and cardiovascular disorders. Finally, exploring the synergistic effects of tea oil with other natural compounds and its potential use in combination therapies could open new avenues for its application in integrative medicine. The findings from this study highlight the potential of tea oil as a valuable addition to public health strategies aimed at improving overall health and preventing chronic diseases. Given its rich composition of unsaturated fatty acids, antioxidants, and anti-inflammatory compounds, incorporating tea oil into dietary guidelines could help reduce the risk of cardiovascular diseases, diabetes, and certain cancers. Public health authorities should consider promoting the consumption of tea oil as part of a balanced diet, emphasizing its benefits for heart health, metabolic regulation, and immune support. However, it is essential to provide clear guidelines on the safe and effective use of tea oil, including recommended dosages and potential contraindications, particularly for individuals with specific health conditions or those who are pregnant. Educating the public about the proper use of tea oil and its potential health benefits can empower individuals to make informed dietary choices that support their long-term health and well-being. Acknowledgments Sincerely thanks the reviewers for their constructive criticisms and suggestions during the review process. These feedbacks not only helped us improve the structure and content of the paper but also provided valuable insights for our future research work. Conflict of Interest Disclosure The author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Cao S., Zhao C., Gan R., Xu X., Wei X., Corke H., Atanasov A., and Li H., 2019, Effects and mechanisms of tea and its bioactive compounds for the prevention and treatment of cardiovascular diseases: an updated review, Antioxidants, 8(6): 166. https://doi.org/10.3390/antiox8060166 Carson C., Hammer K., and Riley T., 2006, Melaleuca alternifolia (tea tree) oil: a review of antimicrobial and other medicinal properties, Clinical Microbiology Reviews, 19: 50-62. https://doi.org/10.1128/CMR.19.1.50-62.2006 Cox S., Mann C., Markham J., Gustafson J., Warmington J., and Wyllie S., 2001, Determining the antimicrobial actions of tea tree oil, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 6: 87-91. https://doi.org/10.3390/60100087 Dludla P., Nkambule B., Mazibuko-Mbeje S., Nyambuya T., Orlando P., Silvestri S., Marcheggiani F., Cirilli I., Ziqubu K., Ndevahoma F., Mxinwa V., Mokgalaboni K., Sabbatinelli J., Louw J., Louw J., and Tiano L., 2020, Tea consumption and its effects on primary and secondary prevention of coronary artery disease: Qualitative synthesis of evidence from randomized controlled trials, Clinical Nutrition ESPEN, 41: 77-87. https://doi.org/10.1016/j.clnesp.2020.11.006 Fang J., Sureda A., Silva A., Khan F., Xu S., and Nabavi S., 2019, Trends of tea in cardiovascular health and disease: a critical review, Trends in Food Science and Technology, 88: 385-396. https://doi.org/10.1016/J.TIFS.2019.04.001 He L., Guoying Z., Huaiyun Z., and Junang L., 2011, Research progress on the health function of tea oil, Journal of Medicinal Plants Research, 5: 485-489. Kairey L., Agnew T., Bowles E., Barkla B., Wardle J., and Lauche R., 2023, Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—a systematic review of randomized controlled trials, Frontiers in Pharmacology, 14: 1116077. https://doi.org/10.3389/fphar.2023.1116077 Keller A., and Wallace T., 2021, Tea intake and cardiovascular disease: an umbrella review, Annals of Medicine, 53: 929-944. https://doi.org/10.1080/07853890.2021.1933164
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