Bioscience Evidence 2024, Vol.14, No.2, 39-43 http://bioscipublisher.com/index.php/be 42 Figure 4 A prominent role for CAL enzymes in early Lycopodium alkaloid biosynthesis Figure 5 depicts the metabolic network for the generation of the optimized acetylcholinesterase (AChE) inhibitor HupA (compound 17). Enzymes that are newly emerged or previously described enzymes with new reactions are marked in purple. All lycopodium alkaloids with generic names have been validated through real standard substances. The figure also displays the IC50 values of lycopodium alkaloids inhibiting AChE. References for these values can be found in the methods section. The stereochemistry of the methyl in compound 9 is based on the typical stereochemistry observed in isolated lycopodium alkaloids. Figure 5 A metabolic network for the generation of an optimized AChE inhibitor, HupA (17)
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