Bioscience Evidence 2024, Vol.14, No.1, 11-15 http://bioscipublisher.com/index.php/bm 13 Table 1 Cardiometabolic profile, example loci and physiological effect of index SNVs at T2D association signals allocated to eight mechanistic clusters Figure 2 presents a heatmap based on single-cell ATAC-seq peak values indicating regions of open chromatin associated with Type 2 Diabetes (T2D). Panels a and b respectively show 222 cell types from 30 adult and 15 fetal tissues, and 106 cell types from the human brain. The columns of the heatmap correspond to different mechanistic clusters, and the rows correspond to cell types. The 'temperature' of each cell indicates the logarithm of the fold enrichment for T2D association. Rows marked with an asterisk signify cell types that show significant enrichment for T2D association within at least one cluster (after Bonferroni correction). For instance, islet cells and certain cell types in the nervous system display open chromatin areas significantly associated with T2D, potentially offering insights into the cell-specific genetic regulation of T2D. Figure 2 Heat map of cluster-specific enrichments of T2D associations for cell-type-specific regions of open chromatin derived from single-cell ATAC-seq peaks in adult and fetal tissue Figure 3 shows the associations between cluster-specific components of partitioned polygenic scores (PS) and five vascular outcomes related to Type 2 Diabetes (T2D) across a cohort of 279,552 individuals from multiple ethnic
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