Bioscience Evidence 2024, Vol.14, No.1, 11-15 http://bioscipublisher.com/index.php/bm 12 Figure 1 Heat map of associations of 37 cardiometabolic phenotypes with 8 mechanistic clusters of index SNVs for T2D association signals Table 1 summarizes the cardiometabolic characteristics, example loci, and physiological effects of index SNV signals related to Type 2 Diabetes (T2D) across eight mechanistic clusters. For instance, the "Beta cell +PI" cluster is associated with increased fasting glucose, two-hour glucose, glycated hemoglobin, and proinsulin levels, but does not affect insulin secretion, influencing insulin sensitivity instead. Conversely, the "Obesity" cluster is related to an increase in body mass index (BMI), waist-hip ratio, body fat, and basal metabolic rate, but it is linked to a decrease in high-density lipoprotein (HDL) cholesterol levels. These clusters reveal the impact of specific genetic loci on T2D risk phenotypes, indicating that the development of T2D is associated with various metabolic pathways, each potentially driven by different genetic variations. These findings contribute to unveiling the complex genetic and metabolic network underlying T2D and provide potential targets for future treatments.
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