International Journal of Marine Science, 2024, Vol.14, No.2, 94-101 http://www.aquapublisher.com/index.php/ijms 94 Research Report Open Access Pharmacological Effects and Biological Activity Evaluation of Marine Bioactive Substances QiongChen Zhuji Gewuzhihe Biotechnology Co., Ltd, Zhuji, 311800, Zhejiang, China Corresponding email: 2314548193@qq.com International Journal of Marine Science, 2024, Vol.14, No.2, doi: 10.5376/ijms.2024.14.0012 Received: 19 Feb., 2024 Accepted: 01 Apr., 2024 Published: 25 Apr., 2024 Copyright © 2024 Chen, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Chen Q., 2024, Pharmacological effects and biological activity evaluation of marine bioactive substances, International Journal of Marine Science, 14(2): 94-101 (doi: 10.5376/ijms.2024.14.0012) Abstract Marine bioactive substances refer to compounds with biological activity extracted from marine organisms, including but not limited to algae, sponges, mollusks, etc. These compounds have attracted great attention due to their widespread applications in fields such as medicine, drug development, and ecology. With the increasing impact of humans on the Earth's ecosystem, the study of marine bioactive substances also involves ecology and environmental science. Protecting marine biodiversity while exploring its potential medical and ecological applications has become an important part of maintaining ecological balance and human health. This review delves into the pharmacological effects and bioactivity assessment of marine bioactive substances, including their concepts, diversity, separation techniques, pharmacological properties, practical application cases, and potential medical applications, challenges, and prospects. However, its research still faces challenges of resource sustainability, high costs, and time investment. To address these issues, researchers encourage in-depth research on marine biodiversity and provide new perspectives in this field. Keywords Active substances; Marine extract; Drug effects; Biodiversity; Medical applications The ocean is one of the most mysterious, diverse, and underexplored ecosystems on Earth, filled with various biodiversity and potential pharmaceutical resources. Since ancient times, humans have been searching for bioactive substances with medicinal potential in the ocean, from the legendary stories of ancient sea explorers to breakthroughs in modern molecular biology and biotechnology. Marine biological resources have always been a hot research topic in the fields of medicine and pharmaceuticals. Research has shown that marine organisms contain a variety of biologically active compounds with anti-cancer, antibacterial, anti-inflammatory, and immunomodulatory properties (Xiao et al., 2022), sparking widespread interest among researchers. Over the past few decades, many studies have made significant breakthroughs in isolating and identifying bioactive substances from marine organisms. For instance, anticancer compounds found in Atlantic seaweed (Nicolini et al., 2023) and antibiotics discovered in Pacific sponges are successful cases. These achievements have provided valuable resources for drug discovery and development. With the advancement of modern scientific and technological capabilities, scholars are unveiling the infinite possibilities in the ocean, which are expected to not only revolutionize the field of drug research and development but also have profound implications for global healthcare. However, despite some successes, the full potential of marine biological resources remains largely untapped, requiring further research and evaluation. This study aims to delve into the pharmaceutical effects and bioactivity of marine bioactive substances, providing a framework for better understanding the nature, potential applications, and future development of these potential drugs. Researchers will explore the discovery and mechanisms of action of marine bioactive substances, revealing their potential applications in the medical field from new perspectives. This will help guide future research and development, bringing more innovation and hope to the global healthcare sector. Through this study, the authors hope to encourage a better utilization of marine biological resources and propel advancements in the field of drug development.
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