International Journal of Molecular Zoology 2024, Vol.14, No.4, 197-210 http://animalscipublisher.com/index.php/ijmz 199 immune and age-related genes in the mutants, indicating that UNC-30 may act as a critical regulator in these biological processes, influencing the organism's response to infection and lifespan. Figure 1 PITX1/UNC-30 regulates immune and age determination pathways (Adopted from Otarigho and Aballay, 2021) Image caption: (A) Gene ontology analysis of upregulated genes in unc-30(ok613) vs WT in both non-infected and P. aeruginosa-infected animals. The cutoff is based on the filtering thresholds of P< 0.05 and arranged according to the representation factor. (B) Representation factors of immune pathways for the upregulated immune genes in unc-30(ok613) vs WT in both non-infected and P. aeruginosa-infected animals. (C) qRT-PCR analysis of immune gene expression in WT and unc-30(ok613) animals. Bars represent means while error bars indicate SD; *p <0.05, **p < 0.001 and ***p < 0.0001. (D) Representation factors of age determination pathways for the upregulated aging genes in unc-30(ok613) vs WT in non-infected animals. (E) Venn diagram showing the age determination genes in each pathway for the upregulated aging genes in unc-30(ok613) vs WT in non-infected animals. (F) qRT-PCR analysis of age determination genes expression in WT andunc-30(ok613) animals. Bars represent means while error bars indicate SD; *p<0.05, **p < 0.001 and ***p< 0.0001 (Adopted from Otarigho and Aballay, 2021) Understanding the molecular mechanisms underlying these pathways can provide insights into the aging process and identify potential targets for interventions aimed at promoting healthy aging and longevity. The interplay between immune function and longevity underscores the importance of maintaining a balanced immune response to ensure both effective pathogen defense and prolonged lifespan.
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