International Journal of Molecular Zoology 2024, Vol.14, No.1, 54-61 http://animalscipublisher.com/index.php/ijmz 60 5 Conclusion and Outlook In the study, the researchers found a close relationship between epigenetic changes and seasonal changes in rabbits. Through in-depth analysis of the epigenome of rabbits in different seasons, the researchers found that there are significant differences in the epigenome of rabbits in winter and summer. This suggests that seasonal changes may be one of the key factors driving epigenetic changes in rabbits. Further research revealed the impact of seasonal changes on gene expression in rabbits (Jaksic et al., 2021). During the cool season, the expression levels of some genes related to adaptation to low-temperature environments increased, while during the hot summer, other genes showed different expression patterns. This seasonal regulation may be to adapt to the ecological pressure in different seasons and maintain the survival advantage of rabbits in various environmental conditions. Although this study achieved some important findings, there are also some limitations that need to be considered. The geographical scope and sample size of the study were relatively limited and may not fully reflect the epigenetic changes in rabbits in different regions and populations. Future research can gain a more comprehensive perspective on understanding epigenetic changes in rabbits in different seasons by expanding the sample range and introducing experimental data from multiple locations. This study mainly focused on the cold and hot seasons in the study of the relationship between seasonal changes and rabbit epigenetics (El-Sayed et al., 2021), but less is known about the effects of transition seasons and other climate conditions. Future research can be expanded to spring and autumn, as well as areas at different latitudes and altitudes, to gain a more comprehensive and in-depth understanding of the mechanisms of seasonal changes in rabbit epigenetics. This study is not only of great significance to understanding rabbit biology, but also provides some useful implications for ecology and agriculture. By in-depth study of epigenetic changes in domestic rabbits under seasonal changes, people can better understand how wild animals adapt to different seasonal environments. This has guiding significance for the stability of ecosystems and animal protection. In terms of agriculture, this study also provides some useful information for animal husbandry. Understanding the epigenetic changes of rabbits in different seasons can provide rabbit farmers with more scientific feeding and management suggestions to optimize breeding efficiency. At the same time, the results of this study may also provide a theoretical basis for seasonal adjustment of agricultural production, thereby better adapting to the impact of climate change on agriculture. References An H.M., Liu W., and Wang X.P., 2021, Advances and perspectives of epigenetic regulation of insect diapause, Acta Entomologica Sinica, 64(4): 510-522. Bhatt R.S., and Sharma S.R., 2009, Seasonal production performance of Angora rabbits under sub-temperate Himalayan conditions, Asian-Australasian Journal of Animal Sciences, 22(3): 416-420. https://doi.org/10.5713/ajas.2009.80326 Cao J.C., Xue L.E., Lan Q., Rao Y.Y., Chen D.J., Lin R.Y., and Xiao T.F., 2023, Research Progress on the Effect of Epigenetic Modification Affecting the Efficiency of Mammalian Somatic Cell Nuclear Transfer, Chinese Journal of Animal Science, 59(3): 7-15. 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