International Journal of Molecular Zoology 2024, Vol.14, No.1, 22-30 http://animalscipublisher.com/index.php/ijmz 28 4.2 The practical application prospects of GWAS research in improving porcine disease resistance The practical application prospect of GWAS lies in the use of identified disease resistance genes for the selection and improvement of pig populations. Through genetic marker-assisted selection (MAS) based on GWAS, the pig breeding industry can more accurately select breeds with good disease resistance. GWAS also provides important targets for gene editing and transgenic technologies, allowing researchers to directly adjust the genetic background of pigs and enhance their disease resistance through genome editing and other means. These practical application prospects will greatly promote the improvement of porcine disease resistance, increase breeding efficiency, and reduce losses. 4.3 Possible future contributions of porcine disease resistance research Although GWAS has achieved impressive results, porcine disease resistance research still faces a series of challenges and unknowns. In the future, researchers need to delve deeper into the functional mechanisms of disease resistance-related genes in order to better utilize these genes for selection and improvement. At the same time, with the continuous development of technology, a new generation of genomics methods and tools will continue to emerge, providing more possibilities for research on porcine disease resistance. Therefore, the possible contribution of future research on porcine disease resistance is to deeply explore gene functions, continuously innovate technological methods, and apply research results to actual breeding production, injecting new vitality into the healthy development of the pig industry. Through GWAS studies, researchers can better understand the genetic basis of porcine disease resistance, predict and improve disease-resistant pig breeds, and provide technical support and theoretical guidance for the sustainable development of the breeding industry. 5 Conclusion The core focus of the research is to reveal the genetic basis of disease resistance in pigs through GWAS technology. The application of GWAS in this field provides researchers with the opportunity to deeply understand porcine disease resistance, thereby providing more effective disease management strategies for the breeding industry (Bai et al., 2021). Through the analysis of large-scale genotypic and phenotypic data, this study can identify candidate genes and SNPs related to disease resistance, and further study their functions and mechanisms of action. The value and significance of GWAS in studying porcine disease resistance cannot be ignored. GWAS can help researchers understand the genetic basis of porcine disease resistance and reveal genetic differences between different breeds or individuals, thereby providing a basis for selective breeding (Uemoto et al., 2021). GWAS can discover new disease-resistant candidate genes and provide new targets and strategies for improving disease resistance. GWAS can also help people understand the complexity and diversity of disease resistance and provide guidance for further research. In future research, people need to further improve GWAS technology and combine it with other bioinformatics and functional genomics methods to deeply explore the genetic basis of disease resistance (Li and Ritchie, 2021). At the same time, researchers also need to strengthen functional research on disease resistance-related genes, reveal their specific mechanisms of action in disease prevention and control, and provide more effective means for disease prevention and treatment. The application of GWAS in porcine disease resistance research provides important tools and methods for people to deeply understand the genetic basis of disease resistance. Through GWAS technology, researchers can discover new disease-resistant genes and SNPs and reveal their mechanisms of action in disease resistance, thus making greater contributions to pig health management and the sustainable development of the breeding industry. In future studies, researchers will continue to deeply explore the potential of GWAS in disease resistance research, and strengthen gene function research to provide more scientific and accurate solutions for disease prevention and control.
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