International Journal of Molecular Zoology 2024, Vol.14, No.1, 18-21 http://animalscipublisher.com/index.php/ijmz 21 mechanisms of cardiac dysplasia and providing new insights into how mutations in the ACTA2 gene affect cardiac function. 3 Evaluation of the Research This study effectively reproduced the cardiac manifestations of human ACTA2 gene mutations by using a zebrafish model, providing a new method for studying cardiac dysplasia and cardiac morphological abnormalities. This not only deepens our understanding of the role of ACTA2 gene in cardiovascular development, but also provides potential new targets for future research on the treatment of heart diseases. 4 Conclusions The mutations in the ACTA2 gene significantly affect cardiac development and function, and the zebrafish model used in this study further confirms the pathogenic role of these mutations in cardiac morphological abnormalities and dysfunction. 5 Access the Full Text Sebastian, W.A., Inoue, M., Shimizu, N. et al. Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model. Nature (2024). https://doi.org/10.1038/s10038-024-01221-0. 6 Acknowledgement I sincerely thank the journal Nature for providing open access papers. This policy has made it convenient for me to access, read, review and disseminate this excellent research paper. Meanwhile, I would like to express my gratitude to Natasha Alexandra for carefully reading this manuscript and providing valuable suggestions for revisions.
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