International Journal of Molecular Veterinary Research, 2024, Vol.14, No.5, 211-218 http://animalscipublisher.com/index.php/ijmvr 217 Future research should focus on expanding the genetic databases for various goat breeds to identify additional resistance markers. Studies should aim to understand the interaction between genetic resistance and environmental factors to optimize breeding strategies. Policymakers should support the development of breeding programs that prioritize disease resistance, ensuring that these programs are tailored to local conditions and breed characteristics. Additionally, there should be a focus on maintaining genetic diversity to prevent adverse effects from high selection pressure. Collaboration between researchers, breeders, and policymakers will be essential to implement effective strategies for enhancing disease resistance in goats. Acknowledgments We sincerely appreciate the opinions of the two peer reviewers, which have made the article more comprehensive Conflict of Interest Disclosure The authors affirm that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Aboshady H., Mandonnet N., Félicité Y., Hira J., Fourcot A., Barbier C., Johansson A., Jonas E., and Bambou J., 2020, Dynamic transcriptomic changes of goat abomasal mucosa in response to Haemonchus contortus infection, Veterinary Research, 51: 1-12. https://doi.org/10.1186/s13567-020-00768-y Aboshady H., Mandonnet N., Johansson A., Jonas E., and Bambou J., 2021, Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection, PLoS One, 16(3): e0248405. https://doi.org/10.1371/journal.pone.0248405 Amayi A., Okeno T., Gicheha M., and Kahi A., 2021, Breeding dairy goats for disease resistance is profitable in smallholder production systems, Small Ruminant Research, 197: 106337. https://doi.org/10.1016/J.SMALLRUMRES.2021.106337 Asif A., Awais M., Qadri S., Ahmad H., and Du X., 2017, Positive selection of IL‐33 in adaptive immunity of domestic Chinese goats, Ecology and Evolution, 7: 1954-1963. https://doi.org/10.1002/ece3.2813 Ateya A., Al-Sharif M., Abdo M., Fericean L., and Essa B., 2023, Individual genomic loci and mRNA levels of immune biomarkers associated with pneumonia susceptibility in Baladi goats, Veterinary Sciences, 10(3): 185. https://doi.org/10.3390/vetsci10030185 Babar M., Hussain T., Ahmad M., Ali A., Abbas K., and Ali M., 2015, Evaluation of Pakistani goat breeds for genetic resistance to Haemonchus contortus,Acta Veterinaria Brno, 84: 231-235. https://doi.org/10.2754/AVB201584030231 Chen Y., Li R., Sun J., Li C., Xiao H., and Chen S., 2022, Genome-wide population structure and selection signatures of Yunling goat based on RAD-seq, Animals, 12(18): 2401. https://doi.org/10.3390/ani12182401 Estrada-Reyes Z., Tsukahara Y., Amadeu R., Goetsch A., Gipson T., Sahlu T., Puchala R., Wang Z., Hart S., and Mateescu R., 2019, Signatures of selection for resistance to Haemonchus contortus in sheep and goats, BMC Genomics, 20: 1-14. https://doi.org/10.1186/s12864-019-6150-y Goetsch A., Tsukahara Y., Gipson T., Hart S., Dawson L., Wang Z., Puchała R., and Sahlu T., 2021, PSXIV-18 Genetic improvement for resistance to gastrointestinal parasitism in growing meat goats and hair sheep through a centralized performance test in the southcentral USA, Journal of Animal Science, 99(Supplement_3): 493-493. https://doi.org/10.1093/jas/skab235.868 Kotze A., and Prichard R., 2016, Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis, Advances in Parasitology, 93: 397-428. https://doi.org/10.1016/bs.apar.2016.02.012 Mandal M., Mishra C., Dash S., Priyadarshini P., Sabat S., Swain L., and Sahoo M., 2018, Genomic insight to the disease resistance in goat, The Pharma Innovation Journal, 7: 98-103. Mpofu T., Nephawe K., and Mtileni B., 2022, Prevalence and resistance to gastrointestinal parasites in goats: a review, Veterinary World, 15: 2442-2452. https://doi.org/10.14202/vetworld.2022.2442-2452 Omar A., Alam M., Thi T., Kamaruzzaman M., Ali M., Binegde T., Du X., and Zhao S., 2019, Assessment of genetic resistance and abomasal tissues expression of Yichang white goat experimentally challenge with Haemonchus contortus infection, Progressive Agriculture, 30(2): 194-208. https://doi.org/10.3329/PA.V30I2.42512
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