International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 32-39 http://animalscipublisher.com/index.php/ijmvr 38 6 Prospects As an experimental model, mice play an important role in scientific research. The relationship between their temperature adaptive regulation and epigenetic marks is not only of great significance in basic scientific research, but also brings insights to the fields of clinical medicine and biotechnology. New application prospects. Research shows that mice adapt to environmental changes by adjusting epigenetic marks when faced with different environmental temperatures. This discovery provides new ideas for exploring the pathogenesis of the disease. For example, many metabolic diseases such as obesity and type 2 diabetes are closely related to the body's ability to adapt to environmental temperature (Ivanova and Blondin, 2021). Therefore, in-depth study of the epigenetic mark mechanism of temperature adaptive regulation in mice is expected to provide new targets and strategies for the prevention and treatment of related diseases. Research on the adaptive regulation of temperature in mice can also help to understand the pathogenesis of neurological and immune system diseases. Temperature adaptive regulation is closely related to the activity of neurons and the function of immune cells (Angilletta Jr et al., 2019). Therefore, through in-depth study of the temperature adaptive regulation mechanism of mice, it is expected to provide information for the treatment and prevention of related diseases. New ideas and methods. Based on existing research results, this study can conclude that mice will adjust the patterns and levels of their epigenetic marks when adapting to different temperature environments (Hawkins and Storey, 2020), and this regulation involves DNA methylation, histone modifications and non-coding RNA and other levels. Changes in these epigenetic marks affect gene expression and cellular function, thereby affecting the mice's ability to adapt to environmental temperatures. Future research can be carried out from the following aspects : in-depth exploration of the mechanism of epigenetic marks in the regulation of temperature adaptation in mice, and further study of the role of epigenetic marks such as DNA methylation, histone modifications and non-coding RNA in mice. The interaction mechanism in the regulation of temperature adaptation in mice reveals its regulatory network and signaling pathways. Explore the potential value of mouse temperature adaptive regulation in clinical applications, combined with mouse model research, explore the clinical application potential of epigenetic mark regulation in metabolic diseases, neurological diseases, immune system diseases and other fields, and develop new treatments Methods and drug targets. To study the long-term effects of environmental factors on epigenetic marks in mice, in addition to temperature, other environmental factors such as diet, light, etc. may also affect epigenetic marks in mice. Future studies could explore the long-term effects of these environmental factors on epigenetic marks in mice, as well as potential effects on mouse health and disease. The relationship between temperature adaptive regulation and epigenetic marks in mice is a research area that has attracted much attention and is of great significance for understanding the adaptation mechanism of organisms to environmental changes and the pathogenesis of diseases. Future research will further reveal the deep-seated mechanisms in this field and bring new breakthroughs and application prospects to the fields of clinical medicine and biotechnology. References Angilletta Jr M.J., Youngblood J.P., Neel L.K., and VandenBrooks J.M., 2019, The neuroscience of adaptive thermoregulation, Neuroscience letters, 692: 127-136. https://doi.org/10.1016/j.neulet.2018.10.046 PMid:30449698 Hawkins L.J., and Storey K.B., 2020, Advances and applications of environmental stress adaptation research, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 240: 110623. https://doi.org/10.1016/j.cbpa.2019.110623 PMid:31778815 He K., Cao X., and Deng X., 2021, Histone methylation in epigenetic regulation and temperature responses, Current Opinion in Plant Biology, 61: 102001. https://doi.org/10.1016/j.pbi.2021.102001 PMid:33508540
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