International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 32-39 http://animalscipublisher.com/index.php/ijmvr 37 5.2 Temperature adaptation and neurological diseases in mice Temperature adaptation in mice is also closely associated with neurological diseases. Studies have shown that changes in environmental temperature can affect the function and structure of the nervous system of mice, thereby affecting their susceptibility to neurological diseases. In a high-temperature environment, mice may experience abnormal excitation of neurons and abnormal release of neurotransmitters, which may lead to the occurrence and exacerbation of neurological diseases such as epilepsy and Parkinson's disease. Some studies have shown that moderate cold stimulation can promote the growth of neurons and the formation of synaptic connections in mice, improve the function of the nervous system, and thereby combat the occurrence and development of neurological diseases. This suggests the potential role of temperature adaptive regulation in preventing and treating neurological diseases, and provides new ideas and methods for the treatment of neurological diseases. 5.3 Mouse temperature adaptability and immune system diseases Temperature adaptation in mice is also closely related to immune system diseases. Studies have found that changes in environmental temperature can affect the function of the immune system and the activity of immune cells in mice, thereby regulating their resistance to immune system diseases. In cold environments, mice generally have enhanced immune cell activity and increased immune response levels, which help protect against infectious diseases. However in extreme high temperature environments, the immune function of mice may be suppressed, and the activity of immune cells and immune response levels decrease, which may increase the risk of immune system diseases such as autoimmune diseases (Figure 2). Therefore, temperature adaptive regulation has an important impact on the occurrence and development of immune system diseases and provides new ideas and methods for the prevention and treatment of immune system diseases. Figure 2 High heat-exposed mice fail to induce adaptive immunity to influenza virus infection (Moriyama and Ichinohe, 2019) It can be seen from the above that there is a close correlation between temperature adaptability of mice and metabolic diseases, neurological diseases, and immune system diseases. In-depth study of the relationship between temperature adaptability of mice and these diseases will help to deeply understand the pathogenesis of the diseases and provide new ideas and methods for the prevention and treatment of related diseases.
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