International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 1-8 http://animalscipublisher.com/index.php/ijmvr 1 Clinical Case Review Open Access Overcoming Feline Calicivirus: Modern Treatment Methods and Comprehensive Management Strategies Wang Zhaolin1, , Lin Xiaofang2 1 Ruipai Pet Hospital, Sanya, 572000, Hainan, China 2 Tropical Animal Medicine Center of Hainan Tropical Agricultural Resources Research Institute, Sanya, 572025, Hainan, China Corresponding author email: 745457309@qq.com International Journal of Molecular Veterinary Research, 2024, Vol.14, No.1 doi: 10.5376/ijmvr.2024.14.0001 Received: 10 Nov., 2023 Accepted: 15 Dec., 2023 Published: 01 Jan., 2024 Copyright © 2024 Wang and Lin, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Wang Z.L., and Lin X.F., 2024, Overcoming feline calicivirus: modern treatment methods and comprehensive management strategies, International Journal of Molecular Veterinary Research, 14(1): 1-8 (doi: 10.5376/ijmvr.2024.14.0001) Abstract This study comprehensively explores modern treatment methods and comprehensive management strategies for feline calicivirus (FCV). By systematically introducing the basic characteristics, epidemiology, and significance of FCV, the research aims and expectations are elucidated. It also provides a detailed analysis of the basic biology and pathology of FCV, including virus structure, genetic diversity, infection pathways, clinical manifestations, and pathological mechanisms. In terms of modern therapeutic methods, the study delves into antiviral treatments, supportive therapy, and treatment strategies for special cases. It focuses on the types and mechanisms of antiviral drugs, the importance of supportive treatment, and considerations for treatment in cases of chronic infection and multi-cat environments. The research showcases the treatment process and outcomes of FCV through a clinical case, thoroughly discussing preventive and comprehensive management strategies. This includes the types, effects, and limitations of vaccines, preventive measures, health management of cat populations, and the importance of educating pet owners.Finally, the study summarizes the current challenges faced in treating and managing FCV and anticipates possible future treatment strategies and health management systems. The goal is to provide valuable reference for veterinary practitioners, promoting a deeper understanding and effective treatment of FCV. Keywords Feline calicivirus (FCV); Modern treatment methods; Comprehensive management strategies; Clinical case studies; Prevention and control Feline calicivirus (FCV) is a major pathogen affecting the health of cat populations, belonging to the Caliciviridae family, a non-enveloped, single-stranded positive-sense RNA virus. It is primarily transmitted through respiratory secretions, saliva, or direct contact, exhibiting high infectivity and widespread prevalence. Common symptoms in cats infected with FCV include oral ulcers, respiratory symptoms, fever, and even pneumonia (Wang, 2023; Gui, 2023). It is worth noting that FCV displays a certain degree of variability, adding complexity to the prevention and control of the disease. The epidemiological characteristics of FCV in cat populations are significant. It not only affects domestic cats but also spreads widely among feral cats, posing a serious public health concern. Although most infections manifest as mild to moderate symptoms, severe cases can occur, leading to fatal diseases, especially in kittens, elderly cats, or immunocompromised cats (Hofmann-Lehmann et al., 2022). Additionally, FCV infections may result in widespread transmission within cat populations, presenting a risk to overall group health. In the face of this challenge, researchers urgently need a deeper understanding of FCV infection mechanisms and exploration of more effective clinical treatment methods. Currently, FCV treatment relies mainly on symptom support and adjunctive therapy, lacking specific antiviral treatment methods. Therefore, research and development of new antiviral strategies, optimization of supportive treatment measures, and the establishment of comprehensive infection management and prevention systems are crucial for controlling and reducing the impact of FCV infections (Guo et al., 2022). This study aims to comprehensively analyze the current clinical treatment status of FCV, explore modern treatment methods, and develop integrated management strategies. Through systematic literature reviews and case
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