International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 32-39 http://animalscipublisher.com/index.php/ijmvr 36 methylation level of genes, thereby regulating gene expression (He et al., 2021). These regulatory mechanisms work together to enable mice to maintain the stability of gene expression in different temperature environments to adapt to environmental changes. Epigenetic marks can also influence temperature adaptation by regulating the rate and stability of gene transcription. In a temperature-changing environment, some epigenetic marks can affect the binding of transcription factors and the assembly of transcription initiation complexes by regulating the histone modification patterns in the promoter regions of certain genes, thereby affecting gene transcription. rate. On the other hand, some epigenetic marks can also affect the stability of mRNA by regulating the histone modification pattern in the transcription termination region of certain genes, thereby affecting the expression level of the gene. These regulatory mechanisms work together to enable mice to quickly adjust gene expression levels in different temperature environments to adapt to environmental changes. 4.2 The mechanism of epigenetic marks in temperature adaptation regulation The mechanism of epigenetic marks in regulating temperature adaptation mainly includes two aspects: one is to regulate the expression level of genes, and the other is to regulate the expression pattern of genes (Pandey et al., 2021). Epigenetic marks can influence temperature adaptation in mice by regulating the expression levels of certain genes. In a temperature-changing environment, some epigenetic marks can affect the binding of transcription factors and the assembly of transcription initiation complexes by regulating the histone modification patterns in the promoter regions of certain genes, thereby affecting gene transcription. rate. On the other hand, some epigenetic marks can also affect the stability of mRNA by regulating the histone modification pattern in the transcription termination region of certain genes, thereby affecting the expression level of the gene. These regulatory mechanisms work together to enable mice to quickly adjust gene expression levels in different temperature environments to adapt to environmental changes. Epigenetic marks can also influence temperature adaptation in mice by regulating the expression patterns of certain genes. In an environment where temperature changes, some epigenetic marks can affect the expression pattern of genes by regulating certain histone modification patterns of certain genes. For example, changes in certain histone modification patterns may cause certain genes to Changes in the transcription start site produce different transcription variants, thereby affecting gene function. These regulatory mechanisms work together to enable mice to adjust gene expression patterns in different temperature environments to adapt to environmental changes. Epigenetic marks regulate the temperature adaptability of mice through multiple mechanisms, including regulating gene expression levels and regulating gene expression patterns. These regulatory mechanisms work together to enable mice to quickly and effectively adjust gene expression in different temperature environments to adapt to environmental changes. 5 Temperature Adaptability and Related Diseases of Mice 5.1 Temperature adaptation and metabolic diseases in mice There is a strong link between temperature adaptation and metabolic disease in mice. Studies have shown that changes in ambient temperature can directly affect the metabolic rate and fat metabolism process of mice, thereby modulating their susceptibility to metabolic diseases. In a high-temperature environment, the metabolic rate of mice usually increases, and the decomposition rate of fat in the body also accelerates, which may lead to weight loss and increase in blood sugar levels, increasing the risk of obesity, diabetes and other metabolic diseases. Some studies have also found that exposure of mice to cold environments can increase the activity of their brown adipose tissue (Peres Valgas da Silva et al., 2019), thereby promoting fat burning, reducing body fat storage, and improving insulin sensitivity., thereby reducing the incidence of metabolic diseases. These findings suggest the important role of temperature adaptability in mice in regulating the occurrence of metabolic diseases, and provide important clues for further exploring the pathogenesis and treatment of metabolic diseases.
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