International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 32-39 http://animalscipublisher.com/index.php/ijmvr 32 Research Article Open Access Study on the Effect of Temperature on Epigenetic Marks in Mice Zhenni Lu Hangzhou Luohuashi Biotechnology Co., Ltd, Hangzhou, 310000, Zhejiang, China Corresponding author email: 1348509309@qq.com International Journal of Molecular Veterinary Research, 2024, Vol.14, No.1 doi: 10.5376/ijmvr.2024.14.0005 Received: 08 Dec., 202 Accepted: 17 Jan., 2024 Published: 09 Feb., 2024 Copyright © 2024 Lu, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Lu Z.N., 2024, Study on the effect of temperature on epigenetic marks in mice, International Journal of Molecular Veterinary Research, 14(1): 32-39 (doi: 10.5376/ijmvr.2024.14.0005) Abstract This study reviews studies on the effects of temperature on epigenetic marks in mice. As an important experimental model, mice achieve adaptive changes in physiological functions by regulating epigenetic marks when adapting to changes in environmental temperature. This study first introduces the physiological characteristics and temperature adaptation mechanism of mice, and then provides a systematic overview of the basic knowledge of epigenetics, including DNA methylation, histone modifications, and non-coding RNA. This study also explored in detail the effect of temperature on epigenetic marks in mice, including its regulatory effects on DNA methylation, histone modifications and non-coding RNAs. The association mechanism between epigenetic marks and temperature adaptation in mice was further analyzed, and its clinical significance and application prospects in related diseases were explored. This study provides an outlook on future research directions and application prospects, and emphasizes the importance of in-depth study of the relationship between temperature adaptive regulation and epigenetic marks in mice to understand the adaptation mechanism of organisms to environmental changes and the pathogenesis of diseases. Keywords Mice; Temperature adaptation; Epigenetic marks; DNA methylation; Histone modification; Non-coding RNA In the field of biology, epigenetics, as an emerging research field, has gradually received widespread attention (Wang et al., 2024). The research objects of epigenetics include DNA methylation, histone modification, non-coding RNA and a series of genetic information transmission methods that do not involve changes in DNA sequence. These epigenetic marks play important roles in regulating gene expression, cell differentiation, development, and disease development. Environmental factors play a crucial role in the growth and development of organisms, and temperature is one of the most basic factors that directly affects the physiological functions of organisms. Temperature changes can cause a series of physiological responses in organisms, including metabolic regulation, gene expression changes, and cell signaling (Somero, 2020). Past research has shown that temperature also has a clear impact on an organism's epigenetic marks. For example, temperature can affect DNA methylation levels, change histone modification patterns, and regulate the expression levels of non-coding RNAs, thereby affecting gene expression and cellular function. As a commonly used experimental model organism, mice play an important role in the study of epigenetics and biological temperature adaptation. Mice have high biological and genetic similarities, and their physiological mechanisms and genomic information have been extensively studied and understood (Rosshart et al., 2019). Therefore, by studying the epigenetic mark response of mice to temperature changes, we can better understand the adaptation mechanism of organisms to environmental temperature, and provide an important reference for human health and disease treatment. This study aims to review the effects of temperature on epigenetic marks in mice, explore its mechanism in biological temperature adaptation regulation, and look forward to its potential applications in clinical treatment and disease prevention. By systematically reviewing relevant research progress, this study hopes to comprehensively understand the impact of temperature on epigenetic marks in mice and its possible biological significance, and provide new ideas and directions for future research.
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