International Journal of Molecular Veterinary Research 2024, Vol.14, No.1, 17-22 http://animalscipublisher.com/index.php/ijmvr 21 clearer insights into the varied responses of cats to FCV infection across different age groups and populations. This aids in enhancing the level of targeted treatment by clinical doctors and veterinarians, ensuring the health of cat populations more effectively. With the continuous advancement of scientific technology, future research on FCV will focus on several key directions: Virological progress: Further understanding the genetic variations, lifecycle, and virus replication mechanisms of FCV can contribute to the discovery of new therapeutic targets (Bordicchia et al., 2021). Vaccine development: The development of next-generation vaccines will be a critical focus, aiming to enhance the breadth and duration of vaccine efficacy to counteract viral mutations. Mechanisms of chronic infection: In-depth exploration of the molecular mechanisms of chronic FCV infection to find more effective treatment methods, possibly involving emerging fields like gene therapy. Epidemiological research: Strengthening global epidemiological monitoring of FCV to understand the seasonal and geographical variations in transmission dynamics, providing data support for precise prevention and control. By combining these future research directions, researchers can hope to further expand their understanding of FCV, improve treatment effectiveness, alleviate the impact of chronic infections, and ultimately achieve better management of this virus. In this process, interdisciplinary collaboration and technological innovation will be crucial driving forces for advancing research. Collective efforts instill confidence in overcoming FCV in the future, protecting beloved cats from its disturbances. References Bai Y.L., Liu J., Gui Y.P., Xia L.M., Gong G.H., Zhu X.Y., Chang X.J., Chen W.F., Ju H.B., Wang J., and Zhao H.J., 2022, Isolation and identification of Calicivirus, Herpesvirus and Influenza Virus in pet cats in Shanghai city, Zhongguo Dongwu Jianyi (China Animal Health Inspection), (3): 13-18. Bordicchia M., Fumian T.M., Van Brussel K., Russo A.G., Carrai M., Le S.J., Pesavento P.A., Holmes E.C., Martella V., White P., Beatty J.A., Shi., and Barrs V.R., 2021, Feline calicivirus virulent systemic disease: Clinical epidemiology, analysis of viral isolates and in vitro efficacy of novel antivirals in Australian outbreaks, Viruses, 13(10): 2040. https://doi.org/10.3390/v13102040 PMid:34696470 PMCid:PMC8537534 Fumian T.M., Tuipulotu D.E., Netzler N.E., Lun J.H., Russo A.G., Yan G.J.H., and White P.A., 2018, Potential therapeutic agents for feline calicivirus infection, Viruses, 10(8): 433. https://doi.org/10.3390/v10080433 PMid:30115859 PMCid:PMC6116245 Hofmann-Lehmann R., Hosie M.J., Hartmann K., Egberink H., Truyen U., Tasker S., Belák S., Boucraut-Baralon C., Frymus T., Lloret A., Marsilio F., Pennisi M.G., Addie D.D., Lutz H., Thiry E., Radford A.D., and Möstl K., 2022, Calicivirus infection in cats, Viruses, 14(5): 937. https://doi.org/10.3390/v14050937 PMid:35632680 PMCid:PMC9145992 Liu D., Zheng Y.T., Yang Y.P., Xu X.Y., Kang H.T., Jiang Q., Yang M.F., Qu L.D., and Liu J.S., 2022, Establishment and application of ERA-LFD method for rapid detection of feline calicivirus, Applied Microbiology and Biotechnology, 106(4): 1651-1661. https://doi.org/10.1007/s00253-022-11785-6 PMid:35089398 Peñaflor-Téllez Y., Trujillo-Uscanga A., Escobar-Almazán J.A., and Gutiérrez-Escolano A.L., 2019, Immune response modulation by caliciviruses, Frontiers in immunology, 10: 2334. https://doi.org/10.3389/fimmu.2019.02334 PMid:31632406 PMCid:PMC6779827 Spiri A.M., Meli M.L., Riond B., Herbert I., Hosie M.J., and Hofmann-Lehmann R., 2019, Environmental contamination and hygienic measures after feline calicivirus field strain infections of cats in a research facility, Viruses, 11(10): 958. https://doi.org/10.3390/v11100958 PMid:31627345 PMCid:PMC6832521 Tao Y.Z., Liu Y.F., and Yang J.D., 2023, Epidemiological investigation of feline herpesvirus and calicivirus in a pet hospital of Zhengzhou, Tianjin Nongxueyuan Xuebao (Journal of Tianjin Agricultural University), (3): 59-62. Tian J., Kang H.T., Huang J.P., Li Z.J., Pan Y.D., Li Y., Chen S., Zhang J.K., Yin H., and Qu L.D., 2020, Feline calicivirus strain 2280 p30 antagonizes type I interferon-mediated antiviral innate immunity through directly degrading IFNAR1 mRNA, PLoS Pathog., 16(10): e100894. https://doi.org/10.1371/journal.ppat.1008944 PMid:33075108 PMCid:PMC7571719
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