Animal Molecular Breeding 2024, Vol.14, No.5, 326-334 http://animalscipublisher.com/index.php/amb 332 genetic model for type 2 diabetes, demonstrating how selective breeding can lead to a higher incidence of specific diseases within certain breeds. Furthermore, the analysis of genetic diversity and inbreeding practices in cat populations indicates that close inbreeding is prevalent and can lead to decreased fertility and increased neonatal mortality. The use of genome sequencing data has been shown to be beneficial in managing breeding programs to avoid the spread of inherited disorders and maintain genetic diversity. The findings underscore the importance of sustainable breeding practices to mitigate the incidence of hereditary diseases in cats. Sustainable breeding involves maintaining genetic diversity and avoiding close inbreeding, which has been linked to various health issues such as decreased fertility and increased susceptibility to diseases. The use of genetic tools and genome sequencing can aid in identifying disease-causing variants and managing pedigrees to ensure healthy breeding outcomes. For example, the study on the traditional Siamese cat population suggests that optimal contribution selection and limiting contributions from other breeds can improve genetic diversity and reduce the spread of hereditary diseases. Additionally, systematic screening and genetic testing can help in early detection and prevention of hereditary conditions, as recommended for ocular diseases in cats. Promoting genetic health in cats requires a multifaceted approach that includes responsible breeding practices, genetic testing, and ongoing research. Breeders should be encouraged to keep comprehensive records and utilize available genetic tools to make informed breeding decisions. Veterinarians play a crucial role in advising breeders and monitoring the health of cat populations, ensuring that genetic diversity is maintained and hereditary diseases are minimized. Collaborative efforts between breeders, veterinarians, and researchers are essential to develop and implement strategies that promote the long-term genetic health of cat populations. By prioritizing sustainable breeding practices and leveraging advancements in genetic research, we can work towards reducing the incidence of hereditary diseases and improving the overall health and well-being of cats. Acknowledgements I would like to thank two anonymous review experts for their support. Conflict of Interest Disclosure Author affirms that this research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest. References Alhaddad H., Khan R., Grahn R., Gandolfi B., Mullikin J., Cole S., Gruffydd-Jones T., Häggström J., Lohi H., Longeri M., and Lyons L., 2013, Extent of linkage disequilibrium in the domestic cat, felis silvestris catus, and its breeds, PLoS ONE, 8(1): e53537. https://doi.org/10.1371/journal.pone.0053537 PMid:23308248 PMCid:PMC3538540 Anderson H., Davison S., Lytle K., Honkanen L., Freyer J., Mathlin J., Kyöstilä K., Inman L., Louviere A., Foran R., Forman O., Lohi H., and Donner J., 2021, Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11 000 domestic cats, PLoS Genetics, 18(6): e1009804. https://doi.org/10.1371/journal.pgen.1009804 PMid:35709088 PMCid:PMC9202916 Balmer L., O'Leary C., Menotti-Raymond M., David V., O’Brien S., Penglis B., Hendrickson S., Reeves-Johnson M., Gottlieb S., Fleeman L., Vankan D., Rand J., and Morahan G., 2020, Mapping of diabetes susceptibility loci in a domestic cat breed with an unusually high incidence of diabetes mellitus, Genes, 11(11): 1369. https://doi.org/10.3390/genes11111369 PMid:33228033 PMCid:PMC7699364 Bott M., and Chahory S., 2022, Epidemiology and clinical presentation of feline presumed hereditary or breed-related ocular diseases in France: retrospective study of 129 cats, Journal of Feline Medicine and Surgery, 24: 1274-1282. https://doi.org/10.1177/1098612X221080598 PMid:35257624 PMCid:PMC10812340 Casal M., 2022, Feline fertility: consequences of inbreeding and implications for reproductive fitness, Journal of Feline Medicine and Surgery, 24: 847-852. https://doi.org/10.1177/1098612X221118755 PMid:36002141 PMCid:PMC10812227
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