Animal Molecular Breeding 2024, Vol.14, No.2, 165-177 http://animalscipublisher.com/index.php/amb 172 For instance, the study on the polymorphism of MC1R, MITF, TYR, TYRP1, and MLPH genes in four Chinese native rabbit breeds revealed 14 genetic variants that play a crucial role in determining coat color (Jia et al., 2021). These genetic markers can be used to predict and select for specific coat colors in breeding programs, ensuring the propagation of desirable traits. Similarly, the use of single-nucleotide polymorphism (SNP) markers from genotyping-by-sequencing data has identified genes such as ASIP, MITF, and KIT that are associated with fur color (Li et al., 2022). These markers can be integrated into breeding strategies to enhance the selection process, making it more precise and efficient. In addition to improving coat color traits, the genetic information obtained from this study can also be used to maintain genetic diversity within rabbit populations. By understanding the genetic basis of coat color variations, breeders can avoid inbreeding and ensure the long-term sustainability of rabbit breeds. The genetic analysis of coat color variations in the Chinese Rex rabbit population provides a comprehensive understanding of the genetic mechanisms underlying coat color traits. This knowledge can be effectively applied in breeding programs to enhance the economic and aesthetic value of domestic rabbits. Figure 2 Genome-wide association with coat colors of Chinese Rex rabbits (Adopted from Zhang et al., 2023) Moreover, the identification of these genetic markers allows for the development of breeding programs that can maintain or enhance the genetic diversity of rabbit populations. By understanding the genetic basis of coat color, breeders can avoid inbreeding and ensure the health and vitality of rabbit populations. This approach not only improves the aesthetic and economic value of rabbits but also contributes to the overall sustainability of rabbit breeding practices. 6.2 Ethical considerations in coat color manipulation While the manipulation of coat color through genetic selection offers numerous benefits, it also raises several ethical considerations. The primary concern is the welfare of the animals involved in breeding programs. Selective breeding for specific traits, such as coat color, can sometimes lead to unintended consequences, including health issues and reduced genetic diversity. Ethical breeding practices must prioritize the well-being of the animals. This includes ensuring that the selection for coat color does not compromise other important traits, such as health, behavior, and overall fitness. For
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