Animal Molecular Breeding 2024, Vol.14, No.1, 72-81 http://animalscipublisher.com/index.php/amb 80 the association between specific DNA methylation patterns and health conditions, researchers can build more accurate disease risk prediction models (Yousefi et al., 2022). This not only helps detect potential health problems in advance, but also provides scientific basis for developing personalized prevention and treatment plans. Based on the aforementioned research results, this study can conclude that DNA methylation plays a key role at multiple levels in Pomeranian epigenetic regulation. From gene expression to individual characteristics, DNA methylation plays an important role in shaping the Pomeranian's genetic profile. This summary not only helps to deepen the understanding of Pomeranian genetics, but also provides useful experience and inspiration for further research on other dog breeds or even mammals. This study’s in-depth exploration of DNA methylation in epigenetic regulation of Pomeranians will not only help unlock the mysteries of gene regulation in this popular pet breed, but will also be more widely used in animal genetics, ecology and medical research. middle. By deeply understanding the epigenetic regulation mechanism of Pomeranians, people can better protect and promote animal health, and provide strong support for scientific research and practice in related fields. The significance of this research is not only to unravel the genetic code of Pomeranians, but also to inject new scientific wisdom into the symbiotic relationship between humans and animals. References Asari Y., Yamazaki J., Thandar O., Suzuki T., Aoshima K., Takeuchi K., Kinoshita R., Kim S., Hosoya K., Ishizaki T., Kagawa Y., Jelinek J., Yokoyama S., Sasaki N., Ohta H., Nakamura K., and Takiguchi M., 2023, Diverse genome‐wide DNA methylation alterations in canine hepatocellular tumours, Veterinary Medicine and Science, 9(5): 2006-2014. https://doi.org/10.1002/vms3.1204 PMid:37483163 PMCid:PMC10508506 Ehrlich M., and Wang R.Y.H., 1981, 5-Methylcytosine in eukaryotic DNA, Science, 212(4501): 1350-1357. https://doi.org/10.1126/science.6262918 PMid:6262918 Inbar-Feigenberg M., Choufani S., Butcher D.T., Roifman M., and Weksberg R., 2013, Basic concepts of epigenetics, Fertility and sterility, 99(3): 607-615. https://doi.org/10.1016/j.fertnstert.2013.01.117 PMid:23357459 Liu F., Wang Y., Gu H., and Wang X., 2023, Technologies and applications of single-cell DNA methylation sequencing, Theranostics, 13(8): 2439. https://doi.org/10.7150/thno.82582 PMid:37215576 PMCid:PMC10196823 Ma J.N., 2023, Research advance of DNA methylation in animal, Sichuan Journal of Zoology, 42(1): 113-120. Mattei A.L., Bailly N., and Meissner A., 2022, DNA methylation: a historical perspective, Trends in Genetics, 38(7): 676-707. https://doi.org/10.1016/j.tig.2022.03.010 PMid:35504755 Mattick J.S., and Makunin I.V., 2006, Non-coding RNA, Human molecular genetics, 15(suppl_1): R17-R29. https://doi.org/10.1093/hmg/ddl046 PMid:16651366 Morales-Nebreda L., McLafferty F.S., and Singer B.D., 2019, DNA methylation as a transcriptional regulator of the immune system, Translational Research, 204: 1-18. https://doi.org/10.1016/j.trsl.2018.08.001 PMid:30170004 PMCid:PMC6331288 Peng J.L., Ruan Z.H., Zeng Q.J., Yin C., Wei Q., Liang H.P., Xie X.H., and Huang J.Z., 2023, Research progress on chicken embryo development and its epigenetic regulation, China Poultry, 45(1): 94-102. Rathod Y., Pankaj V.R.K., Halmandage S., Malasri G., and Antony N., 2023, Sarcoptic mange in a Pomeranian dog: A case study, The Pharma Innovation Journal, 12(3): 1861-1862. Santifort K.M., Carrera I., Bossens K., and Mandigers P.J., 2023, Phenotypic characterization of Pomeranians with or without Chiari-like malformation and syringomyelia, Frontiers in Veterinary Science, 10: 1320942. https://doi.org/10.3389/fvets.2023.1320942 PMid:38169622 PMCid:PMC10758411 Yang X.G., Zhang H.Z., Li J., Xiang H., and He H.H., 2023, Research progress of the DNA methylation in mammalian oocyte and early embryo development, Acta Veterinaria Et Zootechnica Sinica, 54(2): 443-450.
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