Animal Molecular Breeding 2024, Vol.14, No.1, 72-81 http://animalscipublisher.com/index.php/amb 77 epigenetic regulatory information, researchers can more comprehensively analyze the complexity of Pomeranian gene expression regulatory networks. Through the summary of previous research results and the introduction of technical means and methods, this study has a preliminary understanding of the current research status of DNA methylation in Pomeranians. This provides a theoretical and experimental basis for in-depth exploration of the role of DNA methylation in the epigenetic regulatory mechanism of Pomeranians. In the future, with the continuous innovation of technology and the in-depth advancement of research, researchers are expected to more comprehensively and deeply analyze the fine mechanism of Pomeranian DNA methylation in the regulation of genetic traits. 4 The Role of DNA Methylation in Pomeranian Health and Disease 4.1 DNA methylation and immune system The regulation of DNA methylation in the Pomeranian immune system is an important component in the maintenance of immune function and disease resistance (Morales-Nebreda et al., 2019). This regulatory mechanism not only involves the expression level of genes, but also involves the activity of immune-related cells, the construction of immune regulatory networks, and the regulation of inflammatory responses. Exploring in more detail will provide insight into how DNA methylation plays a role in the Pomeranian immune system. The level of DNA methylation in specific gene regions is directly related to the Pomeranian's immune response. In immune cells, changes in DNA methylation levels may lead to changes in the expression levels of immune-related genes. This change may further regulate the activity of Pomeranian immune cells and affect the speed and intensity of their response to external pathogens. Therefore, a deeper understanding of the methylation status of these specific genes will help to unravel the fine regulatory mechanisms of the Pomeranian immune system. Changes in DNA methylation may also affect the construction of immune regulatory networks. The immune system needs to remain balanced to ensure appropriate responses to external threats while avoiding overactivation of the autoimmune response. DNA methylation participates in the regulation of this complex network by regulating the expression of immune-related genes. A deeper understanding of how methylation affects the expression of immune regulatory factors will help reveal the molecular mechanisms underlying balance maintenance in the Pomeranian immune system. Changes in DNA methylation may also affect the regulation of inflammatory responses. Inflammation is an important way in which the immune system fights infection and injury, however, an excessive inflammatory response can lead to immune-mediated diseases. DNA methylation participates in the fine regulation of inflammatory responses by affecting the expression of inflammation-related genes. A deeper understanding of the role of DNA methylation in the regulation of inflammation in the Pomeranian immune system is expected to provide new therapeutic avenues for controlling immune-mediated inflammatory diseases. By studying the role of DNA methylation in Pomeranian immune system in more detail, this study can provide a clearer understanding of the details of immune regulation and open up new research directions for the treatment and prevention of related diseases. 4.2 DNA methylation and nervous system development The normal development and maintenance of functions of the nervous system are the basis for Pomeranian's intelligent behavior and learning ability, and this is closely related to the complex regulation of DNA methylation. Pomeranians are known for their intelligent and sensitive traits, and the development and functional maintenance of their nervous system may be regulated by specific DNA methylation patterns. In terms of neuronal differentiation, studies have shown that DNA methylation is critical for the fate of Pomeranian neurons. Specific methylation patterns may influence gene expression during critical periods of neuronal differentiation, thereby shaping neuronal properties. This kind of regulation is not only related to the type of neurons, but may also play an important role in the performance of Pomeranian's intelligent behavior.
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