Animal Molecular Breeding 2024, Vol.14, No.1, 72-81 http://animalscipublisher.com/index.php/amb 72 Review and Progress Open Access Research on the Role of DNA Methylation in the Epigenetic Regulation Mechanism of Pomeranian Dogs Aiting Zhang Hangzhou Mono Biotechnology Co., Ltd., Hangzhou, 310051, Zhejiang, China Corresponding author email: 1156388701@qq.com Animal Molecular Breeding, 2024, Vol.14, No.1 doi: 10.5376/amb.2024.14.0009 Received: 10 Dec., 2023 Accepted: 21 Jan., 2024 Published: 12 Feb., 2024 Copyright © 2024 Zhang, This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Preferred citation for this article: Zhang A.T., 2024, Research on the role of DNA methylation in the epigenetic regulation mechanism of Pomeranian dogs, Animal Molecular Breeding, 14(1): 72-81 (doi: 10.5376/amb.2024.14.0009) Abstract This study systematically summarizes the importance and mechanism of DNA methylation in epigenetic regulation of Pomeranians, providing in-depth insights into understanding the genetic characteristics of Pomeranians. By discussing the role of DNA methylation in Pomeranian health and disease, this study not only provides strong support for animal genetics research, but also lays the foundation for future breeding and medical applications. Looking to the future, this study encourages more in-depth research to reveal more refined epigenetic regulatory mechanisms, use advanced technological means to deepen our understanding of the function of DNA methylation, and reveal the relationship between DNA methylation and disease through long-term follow-up studies. connections between. This comprehensive study not only has important implications for Pomeranian genetics, but also provides a useful reference for broader animal genetics and medical research. Keywords Pomeranian; Epigenetic regulation; DNA methylation; Health; Diseases Pomeranians are popular for their flexibility, intelligence, and charming appearance, and are one of the common pets in families (Rathod et al., 2023). However, although the genetic basis of Pomeranian dogs has been studied to some extent, an in-depth understanding of their epigenetic regulatory mechanisms is still relatively lacking. Epigenetic regulation refers to the regulation of gene expression at the genome level through DNA methylation, histone modification, etc., without involving changes in the gene sequence itself. As a typical mammal, the Pomeranian's epigenetic regulatory mechanism is of great significance to understanding the genetic characteristics, breeding process, and possible health problems of pets. The impact of epigenetic regulation on genetic expression is a key step in the development and adaptation of organisms to the environment (Yao et al., 2019). It not only participates in various stages of ontogeny, but also interacts with environmental factors to jointly affect gene expression. As a family pet, the understanding of the epigenetic regulation mechanism of Pomeranians can not only provide scientific basis for improving dog breeds and preventing diseases, but also have certain implications for human health research. As a major way of epigenetic regulation, DNA methylation plays a crucial role in genome stability, development and disease (Yang et al., 2023). In the specific species of Pomeranian, this study will focus on the role of DNA methylation in ontogeny, immune system and nervous system development. By studying the specific role of DNA methylation in the epigenetic regulatory mechanism of Pomeranians, this study is expected to provide new ideas and methods for the prevention and treatment of related genetic diseases. The purpose of this study is to deeply explore the epigenetic regulatory mechanism of Pomeranians, with special attention to the DNA methylation process. Through a systematic study of epigenetic regulation in Pomeranians, this study aims to reveal the specific role and regulatory mechanism of DNA methylation in this process. The importance of studying the epigenetic regulation mechanism of Pomeranians is not only to reveal the deep-seated mechanisms of their genetic characteristics, but also to provide theoretical basis for the prevention and treatment of related diseases. This will not only help deepen the understanding of the genetic characteristics of Pomeranians, but may also provide new perspectives for the study of related pet diseases. At the same time, the research results may also provide reference for human genetics and medical research, providing more scientific support for the symbiotic relationship between pets and humans.
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