Animal Molecular Breeding 2024, Vol.14, No.1, 10-18 http://animalscipublisher.com/index.php/amb 15 Figure 3 Expression of MDV1 gene in chicken immune response Key genetic markers are usually located in genomic regions associated with disease resistance and can be used as candidate markers for further functional validation and genetic improvement. Through in-depth study of these key markers, their mechanism of action in regulating disease resistance can be revealed, providing a theoretical basis for disease prevention and treatment. The identified key genes are also one of the important results of disease resistance research. These key genes may be involved in many aspects of the immune system, cell signaling, pathogen recognition, etc., and are of great significance in resolving the molecular mechanisms of disease resistance. The in-depth study of key genetic markers and genes can provide important clues and targets for the genetic improvement of poultry disease resistance. The identification of key genetic markers and genes is one of the important achievements of genome-wide association studies in the study of poultry disease resistance, which provides an important theoretical and practical basis for understanding the genetic mechanism of disease resistance, carrying out genetic improvement and improving the production efficiency of the breeding industry. 3.3 Significance and implications of the findings These two cases demonstrate the potential of GWAS in unraveling the genetic basis of disease resistance in poultry. By identifying genetic markers and genes associated with disease resistance, the research provides valuable information for poultry breeding, enabling breeders to enhance poultry resistance to these diseases through genetic selection. In addition, these findings provide new targets for disease prevention and treatment, helping to develop more effective vaccines and therapeutic strategies. In the long run, these studies are not only important for improving the production performance and welfare of poultry, but also play a positive role in ensuring global food security and promoting sustainable agricultural development. Through continuous and in-depth genetic and immunological research, it is expected that more key genetic factors will be revealed in the future to further promote the development of the poultry industry.
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