Biomaterial and Biomedicine, 2013, Vol.2, No.1, 1-5
http://bb.sophiapublisher.com
4
2003),
mitochondrial damage and inducing the release
of cytochrome C and apoptosis inducing factor.
Moreover, quinine derivatives
viz.,
driamycin, dauno-
rubicin, mitomycin C, streptonigrin and lapachol, can
interfere the DNA and RNA replication and
mitochondrial oxidative pathways or the formation of
super oxide, peroxide and hydroxide radicals as toxic
products in the cell line. Several compounds of
anthro-quinone families (parimycin, trioxacarcins and
gutingimycin) showed antitumor activities (Anibou et al.,
2008;
Gulecha and Sivakuma, 2011; Kumar et al., 2011).
The results obtained in the present study indicated that
extracts of
Aurora globostellata
showed good
cytotoxic potential agent tumour cell lines (Figure 2).
The study suggested that marine sponge extracts can be
used to develop a good anticancer-agent.
Figure 2 The extracts of control and
Aurora globostellata
against Hela cell line
4.
Conclusion
The cytotoxic nature of the compound inhibited the
proliferation of Tumour cells tested. In the present
study experiments were carried using HeLa,
Raw-264.7 and HEK-293 cell lines. The extract of the
sponge was able to inhibit the cell proliferation
significantly. The present study it is concluded that the
16
th
and 18
th
fractions of the sponges
Aurora
globostellata
and
Spirastrella inconstans
var.
moeandrina
Dendy
respectively has rich bioactive
compounds and that compound must be identified
exactly. This will be a panacea for many pandemic
problems.
Acknowledgement
Authors are thankful to Dr. A.J.A.Ranjit Singh, Principal, Sri
Paramakalyani College, Alwarkurichi, Tirunelveli, Tamilnadu,
lab facilities and encouragement. We thankful for supporting
agency of Department of Science and Technology, Govt. of
India, New Delhi.
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