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clinical and parasitological symptoms during the first
3
days of follow-up).
ii) Late clinical failure (if symptoms develop during
the follow-up period from day 4 to day 28 without
meeting the criteria for early treatment failure).
iii) Late parasitological failure (if only parasitemia
reappear without any symptoms, in the period from
day 7 to day 28).
iv) Adequate clinical and parasitological response
(
absence of symptoms and parasitaemia on day 28
(
World Health Organization, 2003; Mohapatra, 2009)).
Fever resolution time, parasitic clearance time, and
recovery of individual organ dysfunction were
determined in all cases of severe malaria. Complete
resolution of organ dysfunction was defined when the
patients have zero MSS (Mohapatra and Das, 2009).
Patients of uncomplicated vivax malaria were treated
with oral chloroquine 25 mg base/kg bw given over 3
days+primaquin as described above for radical cure.
Patients were examined and assessed twice daily until
full recovery. All patients were followed up for 28
days either at the out door or by correspondence.
Analyses were performed with the use of SPSS
software, version 10. Continuous data are presented as
mean±SD if data were normally distributed. Unpaired
data from two groups were compared by two sample t
test. Distribution of categorical variables were
compared with X
2
test and presented as absolute
counts and percentage. A two-tailed probability value
of <0.05 was considered statistically significant. CI
was calculated at the 95% level. Univariate analysis
was done for risk analysis.
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